RVCE established the Biotechnology department in 2002, affiliated to Visvesvaraya Technological University (VTU), Belgaum, with adequate support from the Rashtreeya Sikshana Samithi Trust (R.S.S.T). The UG Programme in Biotechnology is accredited by National Board of Accreditation for 3 years from 2015-2018 and for 5 years from 2008 -2013. Infrastructure facilities of the department are spread over 2044 Sq Meters with well equipped laboratories, lecture halls and departmental library. It also has an air conditioned seminar hall accommodating 120 persons with multimedia facilities. The department library is well stocked with reference books, text books and journals. The B E Biotechnology program became autonomous in 2007 and an independent BoS was constituted to design and develop the curriculum. The department started two PG Programs M.Tech in Biotechnology and M.Tech in Bioinformatics with a sanctioned intake of 18 students each in the year 2011 & 2012 respectively and became autonomous in the year 2016.